Novel Oncology Therapeutics: Targeted Drug Delivery for Cancer

Novel Oncology Therapeutics: Targeted Drug Delivery for Cancer

1 Department of Chemistry, University of Ioannina, GR45110 Ioannina, Greece 2 Cancer Biobank Center, University of Ioannina, GR45110 Ioannina, Greece 3 Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Immunology and Infectiology, Medical University of Vienna, Vienna, Austria 4Department of Clinical Pharmacy and Diagnostics, University of Vienna, Vienna, Austria 5 V...

Nanotechnology for Targeted Delivery in Cancer Therapeutics

Recent advances in nanotechnology has shown tremendous promise to revolutionize cancer therapeutics by generating new therapies that might allow more efficient targeted delivery of anticancer agents to kill cancerous cells or tumors and imaging agents for diagnosis of various cancers. But, before application of nanoparticle-based targeted delivery systems, significant challenges related to clin...

Advances in Targeted Drug Delivery

Advances in Targeted Drug Delivery

Doxorubicin Loaded DNA Aptamer Linked Myristilated Chitosan Nanogel for Targeted Drug Delivery to Prostate Cancer

Recently, specific attention has been paid to aptamers, short DNA or RNA, as a tool for cancer diagnosis and therapy. In the present study MCS nanogels were prepared by Myristate: chitosan at 1:9 ratio and were characterized by several techniques. A selected ssDNA aptamer(Apt) capable of detecting LNCaP cells was linked to Myristilated chitosan nanogels (Apt-MCS) by glutaraldehyde and loaded wi...